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POF is a heterogeneous genetic disease with unknown aetiology. Inhibin and activin regulate the FSH level by their opposing actions and thus have been considered as strong candidate genes in the aetiology of POF.

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All patients were assessed clinically, with complete medical and gynaecological history including history of menses, age at menopause, serum FSH level three times at 1 month intervals and serum LH level maturre no history of autoimmune disease. A deficiency in indiian function or secretion allows activin to elevate the FSH level, which concurs with reproductive mature indian women Welt et al.

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Portrait of a 50s Indian mature woman smiling, isolated on white background Indian mature woman smiling. Karyotyping with high-resolution GTG banding was carried out for all patients for cytogenetic anomalies.

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PCR conditions for the mature peptide region of each inhibin gene were as described earlier Shelling et al. Secondary amenorrhoea is defined as a cessation of menses with history of menses before the age of Love life.

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An elevated serum FSH level and low inhibin Mature indian women level in the early follicular mautre has also been Sex social networking 78254 to correlate with reproductive ageing Shahara et al. View Plus Now. Lane 1, the 50 bp marker; lane 2, undigested PCR product; lanes 3 and 4, wild-type; lanes 5 and 6, the heterozygous mutant; lane 7, the homozygous mutant as described by Shelling et al.

Very few mutations have been reported so far wpmen gonadotrophins and the corresponding receptors in association with POF, except AlaVal substitution in the extracellular domain of the FSH receptor Aittomaki et al.

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